? ? 芳烴與酰基化試劑如酰鹵、酸酐、羧酸、烯酮等在Lewis酸(通常用無水三氯化鋁)催化下發生酰基化反應，得到芳香酮：
這是制備芳香酮類最重要的方法之一，在酰基化中不發生烴基的重排。
反應機理:
反應實例:
參考文獻：
1.? Hasumoto, I., Takatoshi, K., Badea, F. D., Sawada, T., Mataka, S., Tashiro, M. Regioselectivity of Friedel-Crafts acylation of aromatic
compounds with several cyclic anhydrides. Res. Chem. Intermed. 1996, 22, 855-869.
2. Spagnol, M., Gilbert, L., Alby, D. Friedel-Crafts acylation of aromatics using zeolites. Ind. Chem. Library 1996, 8, 29-38.
3. Mahato, S. B. Advances in the chemistry of Friedel-Crafts acylation. J. Indian Chem. Soc. 2000, 77, 175-191.
4.Metivier, P. Friedel-Crafts acylation (eds. Sheldon, R. A.,Bekkum, H.) (Weinheim: Wiley-VCH, New York, 2001) 161-172.
5. Kozhevnikov, I. V. Friedel-Crafts acylation and related reactions catalyzed by heteropoly acids. Appl. Cat. A 2003, 256, 3-18.
6.Galatsis, P., Manwell, J. J., Blackwell, J. M. Indenone synthesis. Improved synthetic protocol and effect of substitution on the intramolecular
Friedel-Crafts acylation. Can. J. Chem. 1994, 72, 1656-1659.
7.Hachiya, I., Moriwaki, M., Kobayashi, S. Hafnium(IV) trifluoromethanesulfonate, an efficient catalyst for the Friedel-Crafts acylation and alkylation reactions. Bull. Chem. Soc. Jpn. 1995, 68, 2053-2060.
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