苯胺，甘油，硫酸和氧化劑?(如PhNO2)反應制備喹啉的反應。
反應機理
甘油在酸性條件下先生成丙烯醛，苯胺對其進行共軛加成β -苯胺基丙醛，關環脫水得到二氫喹啉，氧化得到產物。
反應實例
參考文獻
1. (a) Skraup, Z. H. Monatsh. Chem. 1880, 1, 316. Zdenko Hans Skraup (1850-1910)?was born in Prague, Czechoslovakia. He apprenticed under Lieben at the University?of Vienna. (b) Skraup, Z. H. Ber. 1880, 13, 2086.【Zdenko Hans Skraup (1850-1910)生于捷克斯洛伐克的布拉格。在維亞納大學師從Lieben。】
2. Manske, R. H. F.; Kulka, M. Org. React. 1953, 7, 80-99. (Review).
3. Bergstrom, F. W. Chem. Rev. 1944, 35, 77-277. (Review).
4. Eisch, J. J.; Dluzniewski, T. J. Org. Chem. 1989, 54, 1269-1274.
5. Oleynik, I. I.; Shteingarts, V. D. J. Fluorine Chem. 1998, 91, 25-26.
6. Fujiwara, H.; Kitagawa, K. Heterocycles 2000, 53, 409-418.
7. Ranu, B. C.; Hajra, A.; Dey, S. S.; Jana, U. Tetrahedron 2003, 59, 813-819.
8. Panda, K.; Siddiqui, I.; Mahata, P. K.; Ila, H.; Junjappa, H. Synlett 2004, 449-452.
9. Moore, A. Skraup Doebner–von Miller Reaction. In Name Reactions in Heterocyclic?Chemistry; Li, J. J., Ed.; Wiley: Hoboken, NJ, 2005, pp 488-494. (Review).
10. Denmark, S. E.; Venkatraman, S. J. Org. Chem. 2006, 71, 16681676. Mechanistic?study using 13C-labelled α ，β -unsaturated ketones.
11. Vora, J. J.; Vasava, S. B.; Patel, Asha D.; Parmar, K. C.; Chauhan, S. K.; Sharma, S.?S. E. J. Chem. 2009, 6, 201-206.
12. Fotie, J.; Kemami Wangun, H. V.; Fronczek, F. R.; Massawe, N.; Bhattarai, B. T.?Rhodus, J. L.; Singleton, T. A.; Bohle, D. S. J. Org. Chem. 2012, 77, 2784-2790.
編譯自：Name Reactions （A Collection of Detailed Reaction Mechanisms）, Jie Jack Li, Skraup quinoline synthesis，page 562-563.
