硫代二甘酸二乙酯和α-二酮在堿性條件下縮合得到3,4-二取代噻吩-2,5-二甲酸酯，然后水解生成相應的酸的反應。
反應機理
反應實例
參考文獻
1. Hinsberg, O. Ber. 1910, 43, 901-906.
2. Miyahara, Y.; Inazu, T.; Yoshino, T. Bull. Chem. Soc. Jpn. 1980, 53, 1187-1188.
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Gisselbrecht, J. P. Angew. Chem. Int. Ed. 1996, 35, 1520-1525.
8. Mullins, R. J.; Williams, D. R. Hinsberg Synthesis of Thiophene Derivatives. In Name Reactions in Heterocyclic Chemistry; Li, J. J., Ed.; Wiley: Hoboken, NJ, 2005, pp
199-206. (Review).
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編譯自：Name Reactions （A Collection of Detailed Reaction Mechanisms）, Jie Jack Li, Hinsberg synthesis of thiophenes，page 314-315.
